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Updated: Mar 31, 2026

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
Published on: March 2, 2017
Convergent evolution of twintron-like configurations: One is never enough
Mohamed Hafez1,2, Georg Hausner3
1a Department of Biochemistry ; Faculty of Medicine; University of Montreal ; Montréal , QC Canada.
Abstract:
Introns inserted within introns are commonly referred to as twintrons, however the original definition for twintron implied that splicing of the external member of the twintron could only proceed upon splicing of the internal member. This review examines the various types of twintron-like arrangements that have been reported and assigns them to either nested or twintron categories that are subdivided further into subtypes based on differences of their mode of splicing. Twintron-like arrangements evolved independently by fortuitous events among different types of introns but once formed they offer opportunities for the evolution of new regulatory strategies and/or novel genetic elements.
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