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Should Partial Hydrolysates Be Used as Starter Infant Formula? A Working Group Consensus
Yvan Vandenplas1, Pedro Alarcon, David Fleischer
1*Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium †National Institute of Child Health, Lima, Perú ‡Denver School of Medicine and Children's Hospital Colorado, University of Colorado §Pediatrics, Department of Clinical Sciences, Umeå University, Sweden ||Department of Pediatrics, Children's Hospital, University of Zagreb Medical School, Zagreb, Croatia ¶Centro de Gastroenterologia y Endoscopia pediatricas Gastroped & Dermatosoluciones Ltda', Bogota, Colombia #Department of Nutrition, University of California, Davis **Department of Pediatrics, University of Oklahoma Health Sciences Center and Children's Hospital, Oklahoma City ††Department of Neonatology, University of Liège CHR Citadelle, Liege, Belgium ‡‡Paediatric Department, University of Insubria, Varese, Italy §§Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Israel ||||Department of Translational Medical Science, Section of Paediatrics, University of Naples Federico II, Naples, Italy ¶¶Department of Paediatrics, The Medical University of Warsaw, Poland ##Department of Pediatrics, Emma Children's Hospital-AMC and VU University Medical Center, Amsterdam, The Netherlands ***Research Institute, Department of Pediatrics, Marien-Hospital-Wesel, Wesel, Germany †††Department of Paediatrics, Faculty of Medicine, University of Malaysia, Kuala Lumpur, Malaysia.
Partially hydrolyzed formulas (pHFs) are safe for healthy infant growth. However, more long-term studies are needed to confirm their efficacy and safety before recommending pHFs for all infants when breastfeeding isn't possible.
Area of Science:
- Pediatric Nutrition
- Infant Feeding
- Allergy Prevention
Background:
- Partially hydrolyzed formulas (pHFs) are widely used for infant allergy prevention and managing gastrointestinal issues.
- This review examines the evidence for recommending pHFs for all infants when breastfeeding is not an option.
Framework:
- Literature search of PubMed and Cochrane databases up to December 2014.
- Inclusion of non-randomized trials and studies on preterm infants due to limited data.
- Inquiry for unpublished data from researchers and formula manufacturers.
Implementation:
- Limited data exist on the efficacy and safety of pHFs in healthy term infants.
- Current evidence suggests pHFs are not harmful for infant growth.
- Regulatory bodies consider pHFs nutritionally adequate for term infants.
Implications:
- Long-term data on immune, metabolic, and hormonal effects are lacking.
- Cost is a factor in decision-making for pHF use.
- Further long-term follow-up studies are recommended before widespread adoption of pHFs for all infants.
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