Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

109
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
109
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

109
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
109
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K
Phase II Conjugation Reactions: Overview01:14

Phase II Conjugation Reactions: Overview

1.2K
Conjugation, a key component of phase II biotransformation reactions, is a vital process in drug detoxification. It involves transferring endogenous substances like glucuronic acid, sulfate, and glycine to drugs or their metabolites formed in phase I reactions. These conjugation reactions, often catalyzed by specific enzymes, transform potentially harmful metabolites into inactive, water-soluble forms easily excreted in urine or bile. By enhancing polarity and eliminating pharmacological...
1.2K
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

89
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
89

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-intensity interval training and continuous glucose monitoring-derived glycemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis.

Frontiers in endocrinology·2026
Same author

Clinical characteristics and outcomes of anti-NMDA receptor-dominant autoimmune encephalitis.

Frontiers in neurology·2026
Same author

Integrative multi-omics analysis reveals inflammation-related molecular networks in acute mountain sickness.

Frontiers in immunology·2026
Same author

<i>CEBPD</i> may function as a molecular indicator of fibrotic severity and negative regulator of fibrosis in uterine leiomyoma through regulating EMT progression.

Frontiers in pharmacology·2026
Same author

Effects of high-intensity interval training on glycemic control and cardiometabolic risk factors in adults with prediabetes: a systematic review and meta-analysis.

Frontiers in endocrinology·2026
Same author

Neoadjuvant therapy with anlotinib in a 5-year-old child with advanced papillary thyroid carcinoma: a case report.

Frontiers in pediatrics·2026

Related Experiment Video

Updated: Mar 31, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Targeted polymer-drug conjugates: Current progress and future perspective.

Hongyan Xu1, Haifeng Ma1, Peimin Yang1

  • 1Department of pharmacy, People's Hospital of Linzi District, Linzi, Shandong Province 255400, China.

Colloids and Surfaces. B, Biointerfaces
|October 30, 2015
PubMed
Summary
This summary is machine-generated.

Polymer-drug conjugates offer a promising approach for cancer therapy, enhancing drug delivery to tumors for improved safety and effectiveness. This review highlights recent advances and future directions in targeted polymer therapeutics.

Keywords:
Active targetingCancer therapyDrug deliveryPassive targetingPolymer-drug conjugates

More Related Videos

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

38.5K
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

13.2K

Related Experiment Videos

Last Updated: Mar 31, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

38.5K
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

13.2K

Area of Science:

  • Polymer science and targeted drug delivery in oncology.

Background:

  • Polymer therapeutics, specifically polymer-drug conjugates, are an emerging strategy for cancer treatment.
  • Current methods aim to improve the therapeutic index of anticancer agents by enhancing drug specificity and release kinetics.

Purpose of the Study:

  • To provide an overview of key targeting molecules used in polymer therapeutics.
  • To summarize recent advancements in the development of tumor-targeted polymer-drug conjugates.
  • To present promising future directions in this field.

Main Methods:

  • Systematic review of recent literature on tumor-targeted polymer-drug conjugates.
  • Identification and discussion of important targeting molecules for cancer therapy.

Main Results:

  • Significant progress has been made in designing smart polymer-drug conjugates for sustained drug release.
  • Various targeting strategies are being explored to enhance specificity towards tumor cells.
  • The development of polymer therapeutics shows potential for improved cancer treatment outcomes.

Conclusions:

  • Targeted polymer-drug conjugates represent a significant advancement in cancer therapy.
  • Continued research into novel targeting molecules and conjugate designs is crucial for future success.
  • This approach holds promise for more effective and safer cancer treatment options.