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Utility of γ-Glutamyl Transferase in Predicting Troponin Elevation in Emergency Departments

Selami Demirelli1, Serdar Firtina2, Lutfu Askin3

  • 1Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey demirelli23@yahoo.com.

Angiology
|October 31, 2015
PubMed

Insights

Serum gamma-glutamyl transferase (GGT) can help predict high troponin levels in acute coronary syndrome (ACS) patients. Higher GGT activity was linked to troponin positivity, suggesting its complementary role in diagnosis.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Serum gamma-glutamyl transferase (GGT) is a known risk predictor for coronary artery disease.
  • Elevated GGT levels are associated with increased cardiovascular morbidity and mortality.

Purpose of the Study:

  • To evaluate the clinical utility of GGT activity in predicting high troponin levels in patients with acute coronary syndrome (ACS).
  • To assess GGT as a potential complementary biomarker for troponin positivity in emergency department patients presenting with chest pain.

Main Methods:

  • Cross-sectional study involving 403 patients (200 troponin-positive, 203 troponin-negative) admitted with chest pain.
  • Measurement of serum GGT activity and troponin levels.
  • Statistical analysis including logistic regression and Spearman rank correlation.

Main Results:

  • GGT activity was significantly higher in troponin-positive patients (44 ± 34 U/L) compared to troponin-negative patients (31 ± 26 U/L, P = .001).
  • A GGT cutoff of >25.5 U/L demonstrated 62% sensitivity and 61% specificity for predicting troponin positivity.
  • Logistic regression confirmed a significant predictive value of GGT for troponin positivity, with a moderately strong correlation.

Conclusions:

  • Elevated serum GGT activity is a significant predictor of troponin positivity in ACS patients presenting with chest pain.
  • GGT may serve as a valuable, accessible biomarker to complement troponin testing in the emergency setting.
  • Further research can explore GGT's role in risk stratification and early diagnosis of acute coronary events.

Keywords:
chest painemergency departmenttroponinγ-glutamyl transferase

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