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Association between p16 Promoter Methylation and Thyroid Cancer Risk: A Meta-analysis
Wei Wu1, Sheng-Fu Yang, Fei-Fei Liu
1Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicing, Kunming University of Science and Technology, Kunming, Yunnan, China
Background:
The aim of the meta-analysis was to derive a more precise assessment of the association between p16 promoter methylation and thyroid cancer risk.
Materials And Methods:
The PubMed, Web of Science databases and Chinese CNKI were searched for relevant articles. Ultimately, seventeen case-control studies were included with a total of 804 thyroid cancer cases and 487 controls analysis by R Software (R version 3.1.2) including meta. Crude odds ratios with 95% confidence intervals were calculated using the random-effects model which were used to assess the strength of relationship between p16 methylation and lung carcinogenesis. Funnel plots were carried out to evaluate publication bias.
Results:
The meta-analysis results showed that the frequency of p16 promoter methylation in cancer tissue/blood was significantly higher than that normal tissue/ blood (OR=5.46, 95%CI 3.12-9.55, P<0.0001) by random effects model with small heterogeneity.
Conclusions:
Thus, p16 promoter methylation may be associated with thyroid cancer risk.
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