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Related Concept Videos

Rab Cascades01:25

Rab Cascades

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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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[Santa Rosa de Lima]

J J Noguera Paláu1

  • 1Oftalmología, Pamplona, Navarra, España.

Archivos De La Sociedad Espanola De Oftalmologia
|October 31, 2015
PubMed
Summary

No abstract available in PubMed .

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