Related Experiment Video

Updated: Mar 31, 2026

Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

21.2K

Bacterial munch for infants: potential pediatric therapeutic interventions of probiotics

Mohsin Khurshid1,2, Bilal Aslam2, Muhammad Atif Nisar2

  • 1College of Allied Health Professionals, Directorate of Medical Sciences, Government College University, Faisalabad, Pakistan.

Future Microbiology
|October 31, 2015
PubMed

Insights

Probiotics, live microorganisms influencing gut microbiota, show promise for infant health. Further research is needed to confirm benefits and understand mechanisms in pediatric gut health.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Immunology

Background:

  • Probiotics are live microorganisms that can modify host gastrointestinal microbiota.
  • Gut flora plays a crucial role in host metabolism, defense, and immune regulation.
  • Recent advancements highlight the clinical significance of probiotics.

Purpose of the Study:

  • To review the postnatal development of gut flora.
  • To evaluate the role of probiotics in infant health and disease.
  • To assess the current evidence for probiotic efficacy in pediatric conditions.

Main Methods:

  • Literature review of scientific advancements in probiotic formulations.
  • Analysis of randomized clinical trials on probiotics for various infant conditions.
  • Examination of studies on gut flora development and probiotic interventions.

Main Results:

  • Preliminary results from clinical trials show promise for probiotics in conditions like necrotizing enterocolitis and antibiotic-associated diarrhea.
  • Probiotics may improve digestion and immune function in infants.
  • The exact mechanisms and reproducibility of probiotic effects require further investigation.

Conclusions:

  • Probiotics hold potential for modulating infant gut microbiota and improving health outcomes.
  • More research is essential to validate findings and elucidate mechanisms of action.
  • Understanding probiotic roles is critical for pediatric health and disease management.

Keywords:
Bifidobacteriaclinical trialsmetagenomemicrobiotanecrotizing enterocolitis

More Related Videos

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.6K
Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice12:12

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Published on: February 8, 2016

13.2K

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.4K
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
34
Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
183
Bacterial Transformation01:33

Bacterial Transformation

In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
63.0K
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
37
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
712