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Published on: August 15, 2019
SeqSIMLA2_exact: simulate multiple disease sites in large pedigrees with given disease status for diseases with low
1Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
Unlabelled:
It is difficult for current simulation tools to simulate sequence data in a pre-specified pedigree structure and pre-specified affection status. Previously, we developed a flexible tool, SeqSIMLA2, for simulating sequence data in either unrelated case-control or family samples with different disease and quantitative trait models. Here we extended the tool to efficiently simulate sequences with multiple disease sites in large pedigrees with a given disease status for each pedigree member, assuming that the disease prevalence is low.
Availability And Implementation:
SeqSIMLA2_exact is implemented with C++ and is available at http://seqsimla.sourceforge.net.
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