Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Kappa opioid receptors mediate aversion-and it matters.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Same author

Epigenome-wide association study of psilocybin-induced methylome changes in alcohol use disorder.

Translational psychiatry·2026

Same author

Investigating Factors Associated With Spontaneous Remission in Individuals With Alcohol Use Disorder-Results From a Multi-Site Longitudinal Cohort Study.

Addiction biology·2026

Same author

Oxa-noribogaine reduces alcohol drinking through aversion learning and by altering glutamatergic activity in the mPFC.

Research square·2026

Same author

Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons.

eLife·2026

Same author

Engaging Gut-to-Brain Signalling to Treat Alcohol Use Disorder.

Addiction biology·2026

Search research articles

Related Experiment Video

Updated: Mar 31, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Quantification of alcohol drinking patterns in mice.

Manuela Eisenhardt^1,2, Sarah Leixner^1,2, Rainer Spanagel¹

¹Institute of Psychopharmacology.

Addiction Biology

|October 31, 2015

Summary

This summary is machine-generated.

Researchers developed a precise, automated system to monitor alcohol consumption in mice. This new technology enhances the study of alcohol addiction genetics and neurobiology by detecting subtle drinking behaviors.

Keywords:

Alcohol Period 1 (Per1)alcohol deprivation effect (ADE)circadian intake drinkometer intake pattern mGluR5 mice quinine yohimbine

More Related Videos

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Related Experiment Videos

Last Updated: Mar 31, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Area of Science:

Neuroscience
Genetics
Behavioral Science

Background:

Mice are crucial models for understanding alcohol addiction's genetics and neurobiology.
Traditional home-cage paradigms offer limited precision in monitoring alcohol intake.
A need exists for more accurate methods to study alcohol drinking behavior in mice.

Purpose of the Study:

To develop and validate a highly precise, automated system for monitoring alcohol consumption in mice within their home cages.
To improve the detection of subtle alcohol drinking patterns relevant to alcohol use disorders.

Main Methods:

Development of a fully automated drinkometer system for home-cage monitoring.
Testing the system's ability to detect differences in drinking behavior in various experimental conditions.

Main Results:

The automated drinkometer system successfully detected differences in alcohol consumption in transgenic mice.
The system identified changes in drinking behavior following alcohol deprivation and stress applications.
These behavioral changes were often undetectable by classical home-cage paradigms.

Conclusions:

The developed drinkometer system provides disturbance-free, high-resolution monitoring of mouse alcohol consumption.
It enables detailed analysis of micro-drinking and circadian patterns in genetically modified and inbred mice.
This technology represents a significant advancement for studying alcohol use disorder-related behaviors.