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Updated: Mar 31, 2026

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Published on: November 21, 2023
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EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part IV - EUS-guided Interventions: General aspects and
C Jenssen1, M Hocke2, P Fusaroli3
1Department of Internal Medicine, Krankenhaus Märkisch Oderland Strausberg/Wriezen, Germany.
Summary
This guideline details endoscopic ultrasound-guided sampling, a minimally invasive technique for gastrointestinal lesion diagnosis and therapy. It provides evidence-based recommendations for safe and effective EUS-guided tissue acquisition.
Area of Science:
- Gastroenterology and Endoscopy
- Medical Imaging
- Interventional Ultrasound
Background:
- Endoscopic ultrasound (EUS) integrates advanced imaging with tissue acquisition.
- EUS enables visualization and biopsy of lesions within and near the gastrointestinal tract.
Purpose of the Study:
- To provide guidelines on diagnostic and therapeutic interventional endoscopic ultrasound.
- To assess the evidence for endoscopic ultrasound-guided sampling.
- To offer clinical practice recommendations for EUS-guided sampling.
Main Methods:
- Review of current evidence on EUS-guided sampling.
- Comparison of EUS-guided biopsy with image-guided percutaneous biopsy.
- Analysis of indications, contraindications, techniques, and adverse events.
Main Results:
- EUS-guided sampling is a safe and effective method for tissue acquisition.
- Guidelines address crucial preconditions, performance steps, and training for EUS-guided sampling.
- Evidence supports the clinical utility of EUS-guided sampling.
Conclusions:
- EUS-guided sampling offers significant advantages for diagnosing and treating gastrointestinal lesions.
- Recommendations are provided for optimizing the safety and reliability of EUS-guided procedures.
- The guideline emphasizes the importance of cytopathological reporting in EUS-guided sampling.
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