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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Selenium and Preeclampsia: a Systematic Review and Meta-analysis
Min Xu1, Dan Guo2,3, Hao Gu2,3
1Department of Obstetrics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
Low blood selenium levels are linked to preeclampsia risk. Selenium supplementation significantly reduces preeclampsia incidence, but more research is needed on optimal dosage and timing.
Area of Science:
- Obstetrics and Gynecology
- Nutritional Science
- Biochemistry
Background:
- Conflicting evidence exists regarding the relationship between selenium concentration and preeclampsia.
- The precise role of selenium in preeclampsia development remains unclear.
Purpose of the Study:
- To compare blood selenium levels in preeclampsia patients versus healthy pregnant women.
- To evaluate the efficacy of selenium supplementation in preventing preeclampsia.
Main Methods:
- A meta-analysis of observational studies and randomized controlled trials (RCTs).
- Searched PubMed, ScienceDirect, Cochrane Library up to November 25, 2014.
- Analyzed mean difference for blood selenium levels and relative risk for preeclampsia incidence.
Main Results:
- Observational studies showed a significant inverse association between blood selenium levels and preeclampsia risk (mean difference -6.47 μg/l).
- RCTs indicated that selenium supplementation reduced preeclampsia risk (relative risk 0.28).
Conclusions:
- Evidence suggests an inverse association between selenium levels and preeclampsia.
- Selenium supplementation appears to significantly decrease preeclampsia incidence.
- Further prospective trials are necessary to determine optimal selenium supplementation strategies.
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