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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Long non-coding RNAs in corticogenesis: deciphering the non-coding code of the brain.

Julieta Aprea1, Federico Calegari2

  • 1DFG-Research Center and Cluster of Excellence for Regenerative Therapies, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

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Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are abundant and diverse, especially in the brain. This review covers their identification, features, and functions in the mammalian brain.

Keywords:
brain developmentlong non‐coding RNAsneural stem cells

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Area of Science:

  • Genomics
  • Molecular Biology
  • Neuroscience

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their biological roles.
  • Advances in sequencing technologies have revealed the vast abundance and diversity of lncRNAs.
  • Despite their prevalence, few lncRNAs have been functionally characterized.

Purpose of the Study:

  • To review the identification of the non-coding transcriptome.
  • To summarize the general features of lncRNAs.
  • To discuss lncRNA function in the developing and adult mammalian brain.

Main Methods:

  • Literature review of studies on lncRNA identification and characterization.
  • Analysis of genomic organization, evolutionary origin, and expression patterns of lncRNAs.
  • Synthesis of current knowledge on lncRNA functions in the brain.

Main Results:

  • The brain exhibits a high number of expressed lncRNAs, with a significant proportion being tissue-specific and evolutionarily conserved.
  • lncRNAs display diverse genomic organization, origins, expression patterns, and functions.
  • The discovery of novel lncRNAs and RNA classes is rapidly expanding.

Conclusions:

  • lncRNAs represent a significant and complex component of the transcriptome with diverse functions.
  • The mammalian brain is a key area for lncRNA research due to unique expression and conservation patterns.
  • Further research is needed to fully elucidate the functional roles of lncRNAs in brain development and function.