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Immunomodulation: checkpoint blockade etc

William T Curry1, Michael Lim1

  • 1Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts (W.T.C.); Harvard Medical School, Boston, Massachusetts (W.T.C.); Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland (M.L.).

Neuro-Oncology
|October 31, 2015
PubMed

The immune microenvironment is considered a major obstacle to generating an effective antitumor immune response. Checkpoint inhibitors manipulate the co-stimulatory response between antigen-presenting cells and immune cells-or between the tumor and immune cells-to elicit an antitumor immune response that would have otherwise been suppressed. Checkpoint inhibitors have shown great promise in the clinics, and some inhibitors such as anti-CTLA-4 antibodies and anti-PD-1 antibodies have gained FDA approval for certain tumors. Here we will discuss the current state of checkpoint inhibitors, biomarker strategies, and management of associated toxicities in glioblastoma.

Keywords:
biomarkercheckpoint blockadeclinical trialglioblastomaimmunotherapy

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