Related Experiment Video
Updated: Mar 31, 2026
Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
Published on: May 23, 2017
White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy
Maeri Yamamoto1, Itaru Kushima2, Hiroki Kimura1
1Department of Psychiatry Graduate School of Medicine Nagoya University Nagoya Aichi Japan.
Introduction:
Response conflict involves selectively attending to relevant information and suppressing distracting, irrelevant information. The medial frontal cortex (MFC) is considered to be involved in response conflict. However, it remains unclear which white matter connectivity is associated with response conflict. This study aimed to delineate the neural connectivity of response conflict in healthy subjects and investigate the association between white matter microstructure and performance of a response conflict task.
Method:
Twenty-eight healthy subjects underwent functional magnetic resonance imaging (fMRI) during the Flanker task and diffusion MRI. We identified the presupplementary motor area (pre-SMA) using fMRI. Furthermore, we delineated the white matter connectivity between the pre-SMA and the cingulum bundle (CB), which is located in the MFC, using probabilistic tractography. We calculated the mean diffusivity (MD), index of white matter microstructure, of this tract and evaluate the association between MD and performance of the Flanker task.
Result:
The mean MD of this tract was significantly and positively associated with performance of the Flanker task.
Conclusion:
The present study suggests the white matter connectivity between the pre-SMA and the CB is related to the response conflict in healthy subjects and finer white matter microstructure is associated with smaller response conflict.
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