Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic plus local metronidazole and cephazolin in complicated appendicitis: a prospective controlled trial.

T A el-Sefi, H M el-Awady, M I Shehata

    Journal of the Royal College of Surgeons of Edinburgh
    |February 1, 1989
    PubMed
    Summary

    Adding local antibiotics during appendectomy significantly reduces wound sepsis and hospital stays for complicated appendicitis. This study shows local metronidazole and cephazolin are safe and effective adjuncts to systemic antibiotics.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prognostic value of quantitative-PCR versus serology for detection of CMV in pre- and post- transplantation patients.

    The Egyptian journal of immunology·2011
    Same author

    Prophylactic appendicectomy during elective cholecystectomy: effects on morbidity. A prospective controlled study.

    International surgery·1989
    Same author

    The place of antibiotics in the prevention of post-appendicectomy sepsis: a prospective study of 400 cases.

    International surgery·1986
    Same author

    A study of the gross, microscopic and functional anatomy of the thoracic duct and the lympho-venous junction.

    International surgery·1983

    Area of Science:

    • Surgical Infection Prevention
    • Antibiotic Therapy in Surgery
    • Appendicitis Management

    Background:

    • Complicated appendicitis poses a risk of postoperative wound sepsis.
    • Systemic antibiotics are standard but may not fully prevent surgical site infections.
    • Novel strategies are needed to enhance infection control in appendectomy.

    Purpose of the Study:

    • To evaluate the efficacy of local antibiotic instillation in reducing postoperative wound sepsis after appendectomy for complicated appendicitis.
    • To assess the impact of local antibiotic therapy on the duration of postoperative hospital stay.

    Main Methods:

    • A randomized controlled trial involving 100 patients undergoing appendectomy for complicated appendicitis.
    • Patients received systemic metronidazole and cephazolin sodium perioperatively.

    Related Experiment Videos

  • Group A received additional local intraperitoneal and interparietal instillation of metronidazole and cephazolin; Group B received no local antibiotics.
  • Wounds were closed primarily without drainage.

    • Main Results:

    • Postoperative wound sepsis occurred in 8% of patients receiving local antibiotics versus 34% in the control group.
    • The mean postoperative hospital stay was significantly shorter in the local antibiotic group (6.6 days) compared to the control group (8.7 days).
    • One patient in the control group developed a pelvic abscess in addition to wound sepsis.

    Conclusions:

    • A single peroperative instillation of metronidazole and cephazolin into the peritoneum and wound layers is a safe and valuable adjunct to perioperative systemic antibiotics.
    • Local antibiotic instillation significantly reduces postoperative sepsis rates in complicated appendicitis.
    • This approach also leads to a significant reduction in the duration of hospital stay.