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Overcoming drug resistance for tuberculosis
Giovanna Poce1, Mariangela Biava1
1Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, piazzale Aldo Moro 5, I-00185 Roma, Italy.
Future Microbiology
|October 31, 2015
Summary
Tuberculosis (TB) remains a global threat due to poor treatment adherence, leading to drug-resistant strains. This review surveys strategies to overcome drug resistance in TB, emphasizing rapid detection and management.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Tuberculosis (TB) persists as a significant global health challenge.
- Patient non-adherence to treatment fuels the rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB strains.
- Mismanagement of drug-susceptible TB contributes significantly to the emergence of drug resistance.
Purpose of the Study:
- To survey major strategies for overcoming drug resistance in tuberculosis.
- To highlight the need for rapid detection and proper management to combat TB spread and resistance.
Main Methods:
- Literature review of major strategies explored for overcoming drug resistance in TB.
- Analysis of factors contributing to the emergence of drug-resistant TB strains.
Main Results:
- Poor patient adherence is a key driver of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis.
- Misdiagnosis and mismanagement of drug-susceptible TB are strongly linked to the development of drug resistance.
- Effective TB control requires both patient cure and prevention of disease spread.
Conclusions:
- Rapid detection and appropriate treatment are crucial for managing tuberculosis globally.
- Addressing treatment adherence and improving diagnostic/management practices are essential to combat TB drug resistance.
- Developing novel strategies is vital to overcome the challenge of drug-resistant TB.
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