Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain neocortex influence on the mononuclear phagocyte system.

P J Neveu1, P Barnéoud, O Georgiades

  • 1Laboratoire de Psychobiologie des Comportements Adaptatifs, Université de Bordeaux II, France.

Journal of Neuroscience Research
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

'Limiting climate change' or 'finding substitutes': How does action identification influence meat consumption reduction among young adults?

Appetite·2025
Same author

A dark-light emergence test: Study at two times of the nycthemeral cycle in four-and twelve-week-old rats.

Behavioural processes·2014
Same author

Transplantation of cells genetically modified and direct intracerebral gene transfer with an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.

Restorative neurology and neuroscience·2011
Same author

Spontaneous alternation disturbance after lesions of the ventral mesencephalic tegmentum in the rat.

Neuroscience letters·2009
Same author

Partial atlE sequencing of Staphylococcus epidermidis strains from prosthetic joint infections.

Journal of clinical microbiology·2009
Same author

Drug abuse: vulnerability and transition to addiction.

Pharmacopsychiatry·2009

The brain

Area of Science:

  • Neuroimmunology
  • Brain-Immune Interactions

Background:

  • The cerebral neocortex asymmetrically modulates immune responses.
  • Previous studies show left cortical lesions reduce B and T cell responses, while right lesions enhance them.

Purpose of the Study:

  • To investigate the immunomodulatory role of the brain cortex on the mononuclear phagocytic system.
  • To assess the impact of cortical lesions on macrophage activity and response to infection.

Main Methods:

  • Cortical ablation (right or left) in female C3H/He mice.
  • Assessment of peritoneal macrophages post-BCG injection (number, oxidative metabolism via chemiluminescence).
  • Evaluation in a Trypanosoma musculi infection model.

Main Results:

Related Experiment Videos

  • BCG-activated macrophages were reduced in number and oxidative metabolism in left-lesioned mice.
  • Resident peritoneal macrophage number and endocytic activity were unaffected by cortical lesions.
  • Left cortical lesions did not significantly alter the course of Trypanosoma musculi infection despite reduced macrophage numbers.

    • Conclusions:

    • The brain neocortex modulates the mononuclear phagocytic system.
    • Left cortical lesions specifically impact BCG-activated macrophage function.
    • Further research is needed to fully elucidate the brain's role in infectious disease outcomes.