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Dry Powder Coating using Planetary Centrifugal Mixer
Yasunori Miyazaki1, Kaoru Miyawaki, Tomonobu Uchino
1Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Summary
A planetary centrifugal mixer (PCM) effectively dry coats powders with lubricants, improving flowability and wettability. This method enhances drug dissolution without altering crystallinity, offering a novel approach for pharmaceutical powder processing.
Area of Science:
- Pharmaceutical Science
- Materials Science
- Powder Technology
Background:
- Extemporaneous compounding requires standardized methods for quality preparation.
- Planetary centrifugal mixers (PCMs) offer small-scale, contamination-free powder blending.
Purpose of the Study:
- To assess the feasibility of dry powder coating using ordered mixing of fine particles with a PCM.
- To investigate the impact of PCM processing on powder properties and drug dissolution.
Main Methods:
- Cohesive lactose powders were dry coated with magnesium stearate (MgSt) using varying concentrations.
- Operational variables (time, speed, vessel size, charging rate) were tested.
- Surface morphology, flowability, wettability, and ibuprofen dissolution were evaluated.
Main Results:
- Successful dry coating of lactose with MgSt was achieved, creating hydrophobic surfaces.
- Optimized PCM conditions (higher speed, longer time, lower charging rate) improved powder properties.
- Coated ibuprofen exhibited enhanced dissolution profiles without crystallinity changes.
Conclusions:
- PCM is an effective, low-impact tool for dry powder coating.
- This technique can transform crushed tablets into functional powders with improved properties.
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