Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

109
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
109
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

109
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
109

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Albumin Nanoparticles Improve Colistin Performance Against Hetero- and Full-Resistant Clinical <i>A. baumannii</i>: A Mechanistic Study.

Antibiotics (Basel, Switzerland)·2026
Same author

Exploiting Greener Formulations of Benzalkonium Chloride with Enhanced Antibacterial Properties.

ACS omega·2026
Same author

Maltodextrins functionalised with pyrrolidine nitroxides: Synthesis and in vivo follow-up by magnetic resonance imaging.

International journal of biological macromolecules·2026
Same author

Controllable γ-radiation synthesis of conductive polymer-shelled AgNPs nanocomposites with enhanced antibacterial and antibiofilm activities.

International journal of pharmaceutics·2026
Same author

pH-Sensitive Dextrin-Based Nanosponges Crosslinked with Pyromellitic Dianhydride and Citric Acid: Swelling, Rheological Behavior, Mucoadhesion, and In Vitro Drug Release.

Gels (Basel, Switzerland)·2026
Same author

Erratum to "Gemcitabine-loaded ICOS-Fc decorated nanosponges: a new chemo immunotherapy combination against pancreatic cancer". [Int. J. Pharm. 682 (2025) 125869].

International journal of pharmaceutics·2026
Same journal

Bioactivity and Bioavailability of Tea (Camelia sinensis) and Its Possible Effect on Disease Prevention and Health Promotion: A Narrative Review.

Current pharmaceutical biotechnology·2026
Same journal

Therapeutic Applications and Advancements of Exosome-Based Treatments - A Comprehensive Review.

Current pharmaceutical biotechnology·2026
Same journal

Comparative Phytochemical Characterization and Antibacterial Activity of Ethanol and Aqueous Extracts of Moringa peregrina and Moringa oleifera against Multidrug-Resistant Bacteria.

Current pharmaceutical biotechnology·2026
Same journal

Unveiling Aptamers for Targeted Tumour Therapies and Detection: Systematic Evolution of Ligands by Exponential Enrichment (SELEX) Technology in Oncology.

Current pharmaceutical biotechnology·2026
Same journal

Nanosuspensions-Based Dry Powder Inhalers for Pulmonary Delivery of Hydrophobic Natural Products: Formulation Strategies, Efficacy, and Challenges.

Current pharmaceutical biotechnology·2026
Same journal

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Rat Wound Healing by Inhibiting Pyroptosis through the NLRP3/Caspase-1/GSDMD Pathway.

Current pharmaceutical biotechnology·2026
See all related articles

Related Experiment Video

Updated: Mar 31, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.7K

Cyclodextrin-based Polymeric Nanoparticles as Efficient Carriers for Anticancer Drugs.

Dominique Duchene1, Roberta Cavalli, Ruxandra Gref

  • 1Galien Institute, UMR CNRS 8612, Faculty of Pharmacy, University Paris-South, 5 rue Jean Baptiste Clément, 92290 Chatenay Malabry, France. dominique.duchene@u-psud.fr.

Current Pharmaceutical Biotechnology
|October 31, 2015
PubMed
Summary
This summary is machine-generated.

Cyclodextrins enhance chemotherapy by forming nanoparticles, improving the solubility and stability of cancer drugs for better treatment efficacy. This review explores cyclodextrin-based polymeric nanoparticles for advanced cancer therapy.

More Related Videos

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

12.2K
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

6.7K

Related Experiment Videos

Last Updated: Mar 31, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.7K
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

12.2K
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

6.7K

Area of Science:

  • Nanotechnology
  • Polymer Science
  • Medicinal Chemistry

Background:

  • Chemotherapeutic agents often exhibit poor water solubility and stability, limiting their efficacy in cancer treatment.
  • These physico-chemical properties present significant challenges in developing effective drug delivery systems.
  • Cyclodextrins are known for their ability to form molecular inclusions with hydrophobic molecules.

Purpose of the Study:

  • To review the use of cyclodextrins in developing advanced nanoparticle-based drug delivery systems for cancer therapy.
  • To focus on polymeric nanoparticles formulated using cyclodextrin molecules or combinations of polymers and cyclodextrins.
  • To highlight the potential of these systems in overcoming limitations of conventional chemotherapeutic agents.

Main Methods:

  • Review of literature on cyclodextrin-based polymeric nanoparticles for cancer therapy.
  • Analysis of studies focusing on the formulation and characterization of these nanoparticles.
  • Examination of the role of cyclodextrins in improving drug solubility, stability, and delivery.

Main Results:

  • Cyclodextrins can be effectively incorporated into polymeric nanoparticles to encapsulate chemotherapeutic drugs.
  • These nanoparticles demonstrate improved solubility and stability of the loaded drugs.
  • The use of cyclodextrin-based nanoparticles shows promise for enhanced drug efficacy and targeted cancer therapy.

Conclusions:

  • Polymeric nanoparticles incorporating cyclodextrins offer a promising strategy for improving cancer chemotherapy.
  • These systems can overcome the poor physico-chemical properties of many chemotherapeutic agents.
  • Further research into cyclodextrin-based nanoparticles can lead to more effective cancer treatment modalities.