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Updated: Mar 31, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Stereoselective Total Synthesis of (-)-Depudecin
Cristina García-Ruiz1, Iván Cheng-Sánchez1, Francisco Sarabia1
1Department of Organic Chemistry, Faculty of Sciences, University of Málaga , Campus de Teatinos s/n, 29071 Málaga, Spain.
Abstract:
The total synthesis of the natural product depudecin, an antiangiogenic microbial polyketide with inhibitory activity against histone deacetylases, is reported. Characterized by a highly oxidized 11-carbon chain containing two epoxides conjugated through a trans-disubstituted olefin, its total synthesis was efficiently accomplished by a novel asymmetric methodology of epoxide formation based on a new class of chiral sulfonium salts, allowing for the construction of the oxirane rings in an efficient and stereoselective fashion.
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