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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Optimization of Neuromodulation for Bladder Control in a Rat Cystitis Model.

Xin Su1, Angela Nickles2, Dwight E Nelson1

  • 1Neuromodulation Research, Medtronic, Inc, Minneapolis, MN, USA.

Neuromodulation : Journal of the International Neuromodulation Society
|October 31, 2015
PubMed
Summary

Spinal nerve stimulation (SNS) at 10 Hz and high intensity effectively increases functional bladder capacity in a rat model of overactive bladder. This approach attenuates the hypersensitive micturition reflex by activating peripheral nerves.

Keywords:
Bladdercystitiscystometryelectrical stimulationoptimal parameter

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Area of Science:

  • Urology
  • Neuroscience
  • Physiology

Background:

  • Bladder overactivity and cystitis are common conditions causing urinary urgency and frequency.
  • Current treatments for overactive bladder have limitations, necessitating novel therapeutic approaches.
  • Spinal nerve stimulation (SNS) is an emerging technique with potential for modulating bladder function.

Purpose of the Study:

  • To optimize spinal nerve stimulation (SNS) parameters for treating bladder overactivity.
  • To investigate the effects of SNS on urodynamic parameters in a rat model of cystitis.

Main Methods:

  • A rat model of cystitis was induced using intravesical acetic acid infusion.
  • Continuous infusion cystometry and single-fill cystometry were employed to assess bladder function.
  • Spinal nerve electrodes were placed bilaterally under L6 spinal nerves for controlled SNS.

Main Results:

  • 10-Hz SNS, particularly at higher intensities (2x motor threshold), significantly increased functional bladder capacity (infused volume).
  • SNS at 10 Hz and high intensity attenuated the hypersensitive micturition reflex without affecting basal or micturition pressures.
  • 1 Hz and 50 Hz stimulation frequencies were ineffective in altering bladder activity.

Conclusions:

  • Spinal nerve stimulation (SNS) at 10 Hz and high intensity effectively attenuates the hypersensitive micturition reflex.
  • Acute peripheral nerve activation via SNS increases functional bladder capacity.
  • The findings suggest SNS may modulate the afferent arm of the bladder micturition reflex.