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Repeat proteins challenge the concept of structural domains.

Rocío Espada1, R Gonzalo Parra1, Manfred J Sippl2

  • 1Protein Physiology Lab, Dep de Química Biológica, Facultad de Ciencias Exactas y Naturales, UBA-CONICET-IQUIBICEN, Buenos Aires, C1430EGA, Argentina.

Biochemical Society Transactions
|October 31, 2015
PubMed
Summary

Protein repeat units can fold together or independently. Weak links between repeats in repeat-proteins can disrupt cooperative folding, leading to sub-domains and affecting protein dynamics and function.

Keywords:
ankyrin-repeatlocal frustrationrepeat-protein

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