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Related Experiment Videos

Evaluation of the Abbott TDx analyzer.

C W Lee1, H M Lee

  • 1Forensic Science Division, Government Laboratory, Kowloon, Hong Kong.

Journal of Analytical Toxicology
|January 1, 1989
PubMed
Summary

This study validates the Abbott TDx analyzer for rapid opiate detection in blood, liver, and bile. The method offers speed and sensitivity, proving reliable for forensic screening despite limitations in differentiating specific opiates.

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Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry

Background:

  • Immunoassays are widely used for drug analysis.
  • The Abbott TDx analyzer is a common tool for drug screening.

Purpose of the Study:

  • To evaluate the Abbott TDx analyzer for total opiate quantitation in whole blood, liver, bile, and urine.
  • To assess the method's sensitivity, speed, and reliability for forensic applications.

Main Methods:

  • Utilized the Abbott TDx analyzer for immunoassays.
  • Applied dilution and standard addition methods for sample preparation.
  • Correlated results with derivative gas chromatography for validation.

Main Results:

  • Achieved a detection limit of approximately 30 ng/mL in blood and 55 ng/g in liver.
  • Demonstrated high correlation (r > 0.95) with gas chromatography in forensic cases.
  • Identified potential interference from ethanol and dipipanone; inability to differentiate morphine and codeine.

Conclusions:

  • The Abbott TDx analyzer is a rapid and sensitive screening technique for total opiates in blood, liver, and bile.
  • The method is suitable for forensic analysis, requiring minimal sample preparation.
  • Further validation is needed for specific opiate differentiation.

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