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Updated: Mar 31, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
New technologies for measuring intraocular pressure
Julian Garcia-Feijoo1, Jose María Martinez-de-la-Casa1, Laura Morales-Fernandez1
1Servicio de Oftalmología, Hospital Clínico San Carlos, Departamento de Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Cooperative Research Network on Age-Related Ocular Pathology, Visual and Life Quality, Instituto de Salud Carlos III, Madrid, Spain.
Abstract:
The level of intraocular pressure (IOP) is the main known risk factor for the development and progression of glaucomatous optic neuropathy. Despite Goldmann applanation tonometry (GAT) being the gold standard for determining IOP since the last century, its limitations were obvious from the start and include substantial effects of several eye variables such as axial length, curvature, rigidity, and corneal thickness. These limitations have prompted the development of numerous formulas and nomograms designed to compensate for the ocular characteristics effect on GAT, but none of these methods has been entirely satisfactory. Similarly, as a result of efforts to mitigate some of the limitations of conventional tonometry, several new tonometers have appeared on the scene.
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