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Analgesic use and chronic renal disease
D P Sandler1, J C Smith, C R Weinberg
1Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
The New England Journal of Medicine
|May 11, 1989
Summary
Long-term use of phenacetin and acetaminophen, but not aspirin, is linked to an increased risk of chronic kidney disease. Regular analgesic use significantly elevates the odds of developing renal disease.
Area of Science:
- Nephrology
- Epidemiology
- Pharmacology
Background:
- Chronic renal disease is a significant public health concern.
- Analgesic use is a potential risk factor for kidney disease.
Purpose of the Study:
- To investigate the association between analgesic use (phenacetin, acetaminophen, aspirin) and the risk of developing chronic kidney disease.
Main Methods:
- A multicenter case-control study involving 554 adults with newly diagnosed kidney disease and 516 matched controls.
- Data on analgesic use history were collected via telephone interviews.
Main Results:
- Daily analgesic users showed a significantly higher risk of renal disease (odds ratio, 2.79).
- The risk was highest for phenacetin users (adjusted odds ratio, 5.11) and increased for acetaminophen users (adjusted odds ratio, 3.21).
- No increased risk was observed for daily aspirin users (adjusted odds ratio, 1.32).
Conclusions:
- Long-term, regular use of phenacetin is associated with an increased risk of chronic renal disease.
- Long-term, daily use of acetaminophen is independently associated with an increased risk of chronic renal disease.
- Daily aspirin use did not show an increased risk for chronic renal disease in this study.