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Multiple Pituitary Hormone Deficiency, Empty Sella and Ectopic Neurohypophysis in Turner Syndrome
Deep Dutta1, Chitra Selvan, Satinath Mukhopadhyay
1Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research (IPGMER) and Seth Sukhlal Karnani Memorial (SSKM) Hospital, India. Correspondence to: Dr Deep Dutta, Assistant Professor, Department of Endocrinology, PGIMER and Dr. Ram Manohar Lohia (RML) Hospital, 1 Baba Kharak Singh Marg, New Delhi 110001, India. deepdutta2000@yahoo.com.
Background:
Multiple pituitary hormone deficiency and Turner syndrome have overlapping features in peripubertal girls and is a diagnostic challenge.
Case Characteristics:
16-year-old girl having Turner phenotype undergoing evaluation for severe short stature and pubertal arrest.
Observation:
45,X karyotype, and multiple pituitary hormone deficiency with empty sella.
Intervention:
Levothyroxine, growth hormone and ethinyl-estradiol replacement resulted in 11 cm height gain with attainment of puberty over 2 years.
Message:
Patients of Turner syndrome with height <3rd percentile (Turner specific charts) warrant additional pathology evaluation.
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