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HUVEC Tube-formation Assay to Evaluate the Impact of Natural Products on Angiogenesis
Published on: June 24, 2019
Angiosuppressive properties of marine-derived compounds-a mini review
Patrick Y K Yue1, H M Leung2, Adela J Li3
1Department of Biology, Faculty of Science, Hong Kong Baptist University, HKSAR, Kowloon Tong, Hong Kong. patrick@hkbu.edu.hk.
Abstract:
Angiogenesis, formation of new blood vessels from preexisting one, is a critical step of tumorgenesis of solid tumors. Therefore, antiangiogenic therapy is one of the promising approaches to control tumor growth. In the past 20 years, a lot of compounds have been tested for their antiangiogenic properties. Bevacizumab, Avastin®, the first antiangiogenic drug approved by the US FDA, has been widely used in clinic for treating cancer. Indeed, many synthetic compounds are highly toxic and exert side effects even though they are effective in inhibiting neovessel formation and cancer cell growth. Using natural compounds or their derivatives is one of the ways to solve these problems. Sinomenine and ginsenosides are common antiangiogenic and anticancer compounds that are extracted from herbal medicines. Recent findings suggested that marine algae-derived natural pigments also possess similar activities. It has been reported that fucoxanthin from Undaria pinnatifida, Siphonaxanthin from Codium fragile, can inhibit angiogenesis and cancer growth effectively. In conclusion, natural compounds derived from marine algae could provide a novel and safe source for new drug development in anticancer and antiangiogenic properties in the future.
Insights
Marine algae compounds like fucoxanthin show promise as safe, natural alternatives for anti-cancer therapies by inhibiting tumor blood vessel formation (angiogenesis). This research explores natural pigments for novel drug development.
Area of Science:
- Biochemistry
- Pharmacology
- Marine Biology
Background:
- Angiogenesis is crucial for solid tumor growth, making anti-angiogenic therapy a key strategy in cancer treatment.
- While synthetic drugs like Bevacizumab are effective, they often cause toxicity and side effects.
- Natural compounds offer a potential alternative for safer anti-cancer and anti-angiogenic drug development.
Purpose of the Study:
- To explore the potential of natural compounds, particularly marine algae-derived pigments, as anti-angiogenic and anti-cancer agents.
- To identify novel, safe sources for cancer drug development.
Main Methods:
- Review of existing literature on anti-angiogenic compounds.
- Focus on natural products from herbal medicines (Sinomenine, ginsenosides) and marine algae (fucoxanthin, siphonaxanthin).
Main Results:
- Sinomenine and ginsenosides are known anti-angiogenic and anti-cancer compounds.
- Marine algae pigments, specifically fucoxanthin and siphonaxanthin, have demonstrated effectiveness in inhibiting angiogenesis and cancer growth.
- These natural pigments offer a promising avenue for developing new cancer therapies.
Conclusions:
- Natural compounds from marine algae represent a novel and safe source for developing future anti-cancer and anti-angiogenic drugs.
- Marine algae pigments provide a viable alternative to synthetic compounds, potentially reducing toxicity and side effects in cancer treatment.
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