Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Review and Preview01:13

Review and Preview

12.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
12.2K
Review and Preview01:10

Review and Preview

8.9K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.9K
Proofreading01:43

Proofreading

62.1K
Overview
62.1K
Proofreading01:31

Proofreading

9.9K
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...
9.9K
Proofreading01:43

Proofreading

20.1K
20.1K
Journal Bearings01:23

Journal Bearings

1.4K
Journal bearings are mechanical components that support and provide lateral stability to rotating shafts and axles. They are crucial in reducing friction, wear, and vibration in machinery such as engines, turbines, and pumps. The principle behind journal bearings is forming a thin lubricant film between the bearing surface and the rotating shaft, which minimizes direct contact and reduces frictional forces.
To better understand the concept of journal bearings, consider a rope winch with dry or...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardisation of Imaging Surveillance for Patients With Metastatic Melanoma Stopping Immune Checkpoint Inhibitors.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same author

IMMEDIATE POST-ANAESTHESIA CONFUSION AND AGITATION IN ADULT SURGICAL PATIENTS: INCIDENCE AND CLINICAL CORRELATES.

Georgian medical news·2026
Same author

AEROBIC AND RESISTANCE TRAINING SHOW DIVERGENT ASSOCIATIONS WITH INSULIN SENSITIVITY AND SHORT-TERM GLYCEMIC EXPOSURE IN PREDIABETES: A CROSS-SECTIONAL STUDY.

Georgian medical news·2026
Same author

The usability of an electronic health record in a public healthcare facility in South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same author

The impact of the COVID-19 pandemic on maternal mortality in a South African metropole (2020 - 2021): A retrospective cohort study.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same author

Abstracts Association Tunisienne de Médecine Néonatale (ATMN).

La Tunisie medicale·2026
Same journal

Differential effects of high-sucrose and high-fat diets on metabolic syndrome, BBB integrity, and hippocampal Aβ accumulation.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

CRISPR systems in cancer therapeutics and diagnostics.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

Sex-specific effects of fluoxetine on REM sleep deprivation-induced behavioral impairments and BDNF downregulation in rats.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

Gene polymorphism and serum level of RANKL among patients with rheumatoid arthritis: a systematic review and meta-analysis.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

Effect of peniocerol on human meniscal fibrochondrocyte inflammation induced by IL-1β and TNF-α through the NF-κB signaling pathway.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

Integrated density functional theory, molecular docking, and pharmacokinetic modeling of mukonal and its derivatives as inhibitors of the Plasmodium falciparum TFIIH complex (Tfb5 subunit).

Cellular and molecular biology (Noisy-le-Grand, France)·2026
See all related articles

Related Experiment Video

Updated: Mar 31, 2026

BioMEMS and Cellular Biology: Perspectives and Applications
16:30

BioMEMS and Cellular Biology: Perspectives and Applications

Published on: October 1, 2007

10.3K

Editorial.

A A Farooqi1, M Ismail2

  • 1Institute of Biomedical and Genetic Engineering (IBGE) Islamabad Pakistan ammadfarooqi@rlmclahore.com.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|November 2, 2015
PubMed
Summary
This summary is machine-generated.

This review highlights recent advancements in molecular oncology, detailing key mechanisms in cancer development, progression, and therapeutic resistance. It explores novel therapeutic targets and strategies to overcome drug resistance, offering insights into cancer biology and treatment.

More Related Videos

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.4K
Major Components of the Light Microscope
08:08

Major Components of the Light Microscope

Published on: July 30, 2008

25.9K

Related Experiment Videos

Last Updated: Mar 31, 2026

BioMEMS and Cellular Biology: Perspectives and Applications
16:30

BioMEMS and Cellular Biology: Perspectives and Applications

Published on: October 1, 2007

10.3K
Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.4K
Major Components of the Light Microscope
08:08

Major Components of the Light Microscope

Published on: July 30, 2008

25.9K

Area of Science:

  • Molecular Oncology
  • Cancer Biology
  • Therapeutic Resistance

Background:

  • Cancer development involves gene inactivation, oncogene overexpression, apoptosis imbalance, and signaling pathway dysregulation.
  • MicroRNAs (miRNAs) play significant roles as tumor suppressors or oncogenes, influencing cancer progression and therapeutic resistance.
  • Recent research investigates novel therapeutic targets including PARP inhibitors, histone modifications, and natural compounds like Viscum album.

Discussion:

  • Mechanisms of resistance against therapeutics like TRAIL are being elucidated, with strategies explored in preclinical trials.
  • The interplay between signaling pathways (e.g., Notch) and miRNAs is crucial in cancers like head and neck and esophageal cancer.
  • Genetic variations, such as in death receptor 4, can influence cancer susceptibility and progression.

Key Insights:

  • Apoptotic cell death is frequently inactivated in cancer, and strategies to re-activate this pathway are critical for overcoming drug resistance.
  • Lipid accumulation can promote inflammation and activate cancer stem cell-like properties via NFκB activation.
  • Apoptosis Stimulating Proteins of p53 (ASPP) family members exhibit multifunctional roles in cancer, impacting apoptosis and tumor suppression.

Outlook:

  • Further research into miRNA- and transcription factor-based gene regulation can uncover new therapeutic strategies.
  • Understanding the complex interplay of genetic mutations, gene expression, and patient populations is essential for personalized cancer treatment.
  • Exploring natural compounds and novel molecular targets offers promising avenues for future cancer therapies.