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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Paranasal sinus cancer.

Paolo Bossi1, Davide Farina2, Gemma Gatta3

  • 1Head and Neck Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Critical Reviews in Oncology/Hematology
|November 2, 2015
PubMed
Summary

Paranasal sinus cancers are rare head and neck malignancies. Advanced treatments like Intensity Modulated Radiation Therapy and endoscopic surgery improve outcomes, but multicenter trials are needed for better prognosis.

Keywords:
Paranasal sinus cancerschemotherapyenvironmental causesfollow uplate sequelaeprognostic factorsradiotherapystaging-molecular alterationssurgery

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Radiation Oncology

Background:

  • Paranasal sinus cancers are rare, comprising 5% of head and neck malignancies.
  • Histological variety and overlapping features complicate diagnosis, often needing expert interpretation.
  • Treatment complexity necessitates advanced multimodal approaches.

Purpose of the Study:

  • To review current treatment strategies for paranasal sinus cancers.
  • To highlight advancements in surgical and radiation techniques.
  • To emphasize the need for multicenter trials due to disease rarity.

Main Methods:

  • Review of current literature on paranasal sinus cancer treatment.
  • Discussion of surgical advancements, including transnasal endoscopic techniques.
  • Analysis of radiation therapy modalities, including Intensity Modulated Radiation Therapy and charged particle therapy.

Main Results:

  • Locally advanced operable disease treated with surgery and radiation; unresectable cases with chemoradiotherapy.
  • Advanced radiation techniques (IMRT, proton/carbon ion therapy) may improve outcomes and reduce side effects.
  • Transnasal endoscopic surgery and innovative reconstruction techniques enhance surgical treatment.

Conclusions:

  • Multimodal treatment approaches are crucial for paranasal sinus cancers.
  • Technological advancements in surgery and radiation offer improved outcomes and reduced toxicity.
  • Multicenter trials are essential to enhance prognosis and minimize treatment-related effects for these rare cancers.