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Rivaroxaban in preventing venous thromboembolism after arthroplastic surgery in Taiwan
Yun-Chuan Mao1, Shih-Tse Chen2, Chung-Hwan Chen3
1School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
The Kaohsiung Journal of Medical Sciences
|November 2, 2015
Summary
Rivaroxaban effectively reduces thrombosis after joint replacement surgery, showing lower rates than other antithrombotics. This study suggests rivaroxaban offers a cost-effective option for preventing venous thromboembolism in Taiwan.
Area of Science:
- Orthopedic Surgery
- Pharmacology
- Public Health
Background:
- Venous thromboembolism (VTE) is a significant complication following total hip (THA) and total knee arthroplasty (TKA).
- Preventive antithrombotic medications reduce VTE risk but can increase bleeding complications.
- Rivaroxaban, a direct factor Xa inhibitor, is used for VTE prophylaxis after THA/TKA.
Purpose of the Study:
- To evaluate the efficacy and safety of rivaroxaban for VTE prevention in Taiwan.
- To compare rivaroxaban with other antithrombotic agents in the context of joint arthroplasty.
Main Methods:
- Retrospective analysis of 6996 patients from the Taiwan National Health Insurance Research Database (2008-2012).
- Data included antithrombotic prescriptions, costs, and incidence of thrombosis and hemorrhage.
- Comparison of rivaroxaban with heparin analogs for VTE prevention post-THA/TKA.
Main Results:
- The overall postoperative VTE rate was 0.49%.
- Rivaroxaban and heparin analogs demonstrated reduced thrombosis rates compared to other antithrombotics.
- The rivaroxaban group exhibited lower expenditure and hospitalization costs than the heparin analogs group.
Conclusions:
- Rivaroxaban shows promise in reducing thrombosis after joint arthroplasty.
- Rivaroxaban may be a more cost-effective option compared to heparin analogs.
- Further studies on cost-effectiveness and drug safety are recommended for antithrombotic use in joint arthroplasty.
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