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Updated: Mar 31, 2026

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
Published on: September 28, 2017
catRAPID signature: identification of ribonucleoproteins and RNA-binding regions
Carmen Maria Livi1, Petr Klus1, Riccardo Delli Ponti1
1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain and.
Motivation:
Recent technological advances revealed that an unexpected large number of proteins interact with transcripts even if the RNA-binding domains are not annotated. We introduce catRAPID signature to identify ribonucleoproteins based on physico-chemical features instead of sequence similarity searches. The algorithm, trained on human proteins and tested on model organisms, calculates the overall RNA-binding propensity followed by the prediction of RNA-binding regions. catRAPID signature outperforms other algorithms in the identification of RNA-binding proteins and detection of non-classical RNA-binding regions. Results are visualized on a webpage and can be downloaded or forwarded to catRAPID omics for predictions of RNA targets.
Availability And Implementation:
catRAPID signature can be accessed at http://s.tartaglialab.com/new_submission/signature
Contact:
gian.tartaglia@crg.es or gian@tartaglialab.com
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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