Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

1.9K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.9K
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

3.0K
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
3.0K
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

2.0K
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
2.0K
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

2.1K
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
2.1K
Mass Spectrometers01:16

Mass Spectrometers

10.9K
This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
10.9K
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

7.5K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placental pathology in pregnancies complicated by hypertensive disorders of pregnancy and small for gestational age neonates: prevalence and severity of maternal vascular malperfusion in a prospectively collected cohort.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same author

Isotopic Fractionation and Kinetic Isotope Effects of a Purified Bacterial Nitric Oxide Reductase (NOR).

Biochemistry·2025
Same author

Decreased Alpha Klotho Expression in Placentas Exposed to Severe Maternal Vascular Malperfusion.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2024
Same author

Pre-Medications for Non-Emergency Tracheal Intubation in the United States Neonatal Intensive Care Units.

Cureus·2024
Same author

Clonal expansion and rapid characterization of <i>Klebsiella pneumoniae</i> ST1788, an otherwise uncommon strain spreading in Wales, UK.

Microbial genomics·2023
Same author

Organic Biosignature Degradation in Hydrothermal and Serpentinizing Environments: Implications for Life Detection on Icy Moons and Mars.

Astrobiology·2023

Related Experiment Video

Updated: Mar 30, 2026

Analyzing Large Protein Complexes by Structural Mass Spectrometry
15:35

Analyzing Large Protein Complexes by Structural Mass Spectrometry

Published on: June 19, 2010

25.0K

A compact E × B filter: A multi-collector cycloidal focusing mass spectrometer.

Ryan C Blase1, Greg Miller1, Joseph Westlake2

  • 1Southwest Research Institute, 6220 Culebra Road, San Antonio, Texas 78238, USA.

The Review of Scientific Instruments
|November 2, 2015
PubMed
Summary
This summary is machine-generated.

A compact E × B mass spectrometer offers "perfect focus" for portable isotope ratio monitoring. Its design provides high resolution independent of ion energy or direction, enabling precise measurements.

More Related Videos

Microprobe Capillary Electrophoresis Mass Spectrometry for Single-cell Metabolomics in Live Frog Xenopus laevis Embryos
12:16

Microprobe Capillary Electrophoresis Mass Spectrometry for Single-cell Metabolomics in Live Frog Xenopus laevis Embryos

Published on: December 22, 2017

21.3K
Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
08:40

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

5.0K

Related Experiment Videos

Last Updated: Mar 30, 2026

Analyzing Large Protein Complexes by Structural Mass Spectrometry
15:35

Analyzing Large Protein Complexes by Structural Mass Spectrometry

Published on: June 19, 2010

25.0K
Microprobe Capillary Electrophoresis Mass Spectrometry for Single-cell Metabolomics in Live Frog Xenopus laevis Embryos
12:16

Microprobe Capillary Electrophoresis Mass Spectrometry for Single-cell Metabolomics in Live Frog Xenopus laevis Embryos

Published on: December 22, 2017

21.3K
Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
08:40

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

5.0K

Area of Science:

  • Analytical Chemistry
  • Physics

Background:

  • Traditional mass spectrometers can be bulky and complex.
  • The need for portable, high-resolution analytical instruments is growing.

Purpose of the Study:

  • To present a compact and portable E × B mass spectrometer.
  • To demonstrate its
  • perfect focus
  • capabilities for isotope ratio monitoring.

Main Methods:

  • Design and construction of a compact E × B mass spectrometer using permanent magnets.
  • Implementation of a multi-collector Faraday cup system for simultaneous ion beam detection.
  • Characterization of mass resolution, sensitivity, and mass discrimination.

Main Results:

  • Achieved a mass resolution of approximately 400.
  • Demonstrated spatial and energy independence of resolution.
  • Successfully performed isotope ratio monitoring using discrete Faraday cups.

Conclusions:

  • The compact E × B mass spectrometer is a viable option for portable, high-resolution analysis.
  • The
  • perfect focus
  • design enhances measurement accuracy.
  • The device facilitates simultaneous isotope analysis.