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Characterization and Antioxidant Activity of Quercetin/Methyl-β-Cyclodextrin Complexes
Kadri Güleç, Müzeyyen Demirel1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Anadolu University, P.O. Box: 26470, Eskişehir, Turkey. mdemirel@anadolu.edu.tr.
Current Drug Delivery
|November 3, 2015
Summary
This study improved quercetin
Area of Science:
- Pharmacology
- Materials Science
- Biochemistry
Background:
- Quercetin (Qu) is a potent plant-derived antioxidant.
- Its clinical applications are hindered by poor water solubility, stability, and bioavailability.
Purpose of the Study:
- To enhance quercetin's aqueous solubility, dissolution rate, and antioxidant activity.
- To achieve this through complexation with Methyl-β-cyclodextrin (M-β-CD).
Main Methods:
- Complexes were prepared using freeze-drying and evaporation.
- Characterization involved DSC, XRD, NMR, FT-IR, and SEM.
- In-vitro dissolution and DPPH assays evaluated performance.
Main Results:
- Complexation increased quercetin's aqueous solubility by 254-fold.
- Dissolution rate increased approximately 3-fold.
- Antioxidant activity showed a 10% enhancement.
Conclusions:
- Methyl-β-cyclodextrin complexation significantly improves quercetin's solubility and dissolution.
- This approach enhances quercetin's antioxidant potential for broader applications.
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