Related Experiment Video
Updated: Mar 30, 2026
Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium
Published on: July 14, 2020
Using the rd1 mouse to understand functional and anatomical retinal remodelling and treatment implications in
M Kalloniatis1, L Nivison-Smith2, J Chua3
1Centre for Eye Health, University of New South Wales, Kensington, NSW, Australia; School of Optometry and Vision Science, University of New South Wales, Kensington, NSW, Australia; School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand; Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia.
Abstract:
Retinitis Pigmentosa (RP) reflects a range of inherited retinal disorders which involve photoreceptor degeneration and retinal pigmented epithelium dysfunction. Despite the multitude of genetic mutations being associated with the RP phenotype, the clinical and functional manifestations of the disease remain the same: nyctalopia, visual field constriction (tunnel vision), photopsias and pigment proliferation. In this review, we describe the typical clinical phenotype of human RP and review the anatomical and functional remodelling which occurs in RP determined from studies in the rd/rd (rd1) mouse. We also review studies that report a slowing down or show an acceleration of retinal degeneration and finally we provide insights on the impact retinal remodelling may have in vision restoration strategies.
