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Updated: Mar 30, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
Structural Modifications of cis-Glycofused Benzopyran Compounds and Their Influence on the Binding to Amyloid-β
Cristina Airoldi1, Giuseppe D'Orazio2, Barbara Richichi3
1Department of Biotecnology and Bioscience (Btbs), University of Milano-Bicocca, Piazza della Scienza 2, I-20126, Milan, Italy. cristina.airoldi@unimib.it.
Abstract:
A small library of glycofused tricyclic compounds with a central pyran ring chemically modified in the position para to the ring oxygen has been synthesised. The influence of the chemical modification on the structural conformation of the compounds and on their ability to bind Aβ peptide has been evaluated respectively using molecular mechanics (MM) and molecular dynamics (MD) simulations, and STD NMR spectroscopy. The introduction of particularly polar/charged groups leads to the loss of binding ability, without a significant change in the conformation, whilst other substitutions does not significantly affect either the structural conformation or the binding.
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