Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

3.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
3.0K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

6.0K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
6.0K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

6.3K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.3K
Amplifying Signals via Second Messengers01:15

Amplifying Signals via Second Messengers

9.5K
Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
9.5K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.9K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.9K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

15.9K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
15.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phospholipid Scramblase 4 (PLSCR4) Regulates Adipocyte Differentiation via PIP3-Mediated AKT Activation.

International journal of molecular sciences·2022
Same author

Validation study on the child, adult, and parent version of the ARFID module 2.0 for the Eating Disorder Examination.

The International journal of eating disorders·2022
Same author

"Alcohol intoxication by proxy on a NICU" - a case report.

BMC pediatrics·2022
Same author

The Influence of Body Mass Index on the Growth Hormone Peak Response regarding Growth Hormone Stimulation Tests in Children.

Hormone research in paediatrics·2022
Same author

Having siblings promotes a more healthy weight status-Whereas only children are at greater risk for higher BMI in later childhood.

PloS one·2022
Same author

The Influence of Steroid Hormones on Tooth Wear in Children and in Adolescents.

Journal of clinical medicine·2022

Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research
06:25

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

Published on: March 29, 2024

1.7K

Soluble M6P/IGFIIR in the circulation.

Carolyn D Scott1, Wieland Kiess2

  • 1Kolling Institute of Medical Research, Royal North Shore Hospital and University of Sydney, Sydney, Australia.

Best Practice & Research. Clinical Endocrinology & Metabolism
|November 3, 2015
PubMed
Summary

Soluble Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor (M6P/IGFIIR) acts as a carrier for IGF-II and may influence fetal growth. Elevated levels are linked to birth weight and potentially disease later in life.

Keywords:
childhoodcirculating hormone binding proteininsulin-like growth factor IImannose-6-phosphate/IGF-II receptorobesityreceptor

More Related Videos

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

14.4K
A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

4.1K

Related Experiment Videos

Last Updated: Mar 30, 2026

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research
06:25

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

Published on: March 29, 2024

1.7K
Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

14.4K
A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

4.1K

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Developmental Biology

Background:

  • Soluble M6P/IGFIIR functions as a carrier for IGF-II and mannose 6-P proteins.
  • It acts as an antagonist to the cellular M6P/IGFIIR, potentially opposing IGF-II's growth-stimulatory effects.

Purpose of the Study:

  • To investigate the role of soluble M6P/IGFIIR in fetal growth and development.
  • To explore the association of soluble M6P/IGFIIR levels with birth weight and placental weight.
  • To examine the potential of soluble M6P/IGFIIR as a biomarker for disease and treatment monitoring.

Main Methods:

  • Analysis of maternal serum and cord blood M6P/IGFIIR levels.
  • Correlation studies between IGF-II:soluble M6P/IGFIIR ratio and anthropometric measurements (birth weight, placental weight).
  • Review of existing evidence linking soluble M6P/IGFIIR to various disease states.

Main Results:

  • Maternal serum M6P/IGFIIR levels increase in late pregnancy.
  • The IGF-II:soluble M6P/IGFIIR ratio in cord blood strongly correlates with birth weight and placental weight.
  • Elevated soluble M6P/IGFIIR levels are associated with liver cirrhosis and certain tumors.

Conclusions:

  • Soluble M6P/IGFIIR plays a significant role in fetal growth regulation.
  • It may serve as a useful biomarker for monitoring disease progression and treatment efficacy.
  • Further research is needed to fully understand the regulation and function of soluble M6P/IGFIIR in health and disease.