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Soluble M6P/IGFIIR in the circulation

Carolyn D Scott1, Wieland Kiess2

  • 1Kolling Institute of Medical Research, Royal North Shore Hospital and University of Sydney, Sydney, Australia.

Best Practice & Research. Clinical Endocrinology & Metabolism
|November 3, 2015
PubMed

Insights

Soluble Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor (M6P/IGFIIR) acts as a carrier for IGF-II and may influence fetal growth. Elevated levels are linked to birth weight and potentially disease later in life.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Developmental Biology

Background:

  • Soluble M6P/IGFIIR functions as a carrier for IGF-II and mannose 6-P proteins.
  • It acts as an antagonist to the cellular M6P/IGFIIR, potentially opposing IGF-II's growth-stimulatory effects.

Purpose of the Study:

  • To investigate the role of soluble M6P/IGFIIR in fetal growth and development.
  • To explore the association of soluble M6P/IGFIIR levels with birth weight and placental weight.
  • To examine the potential of soluble M6P/IGFIIR as a biomarker for disease and treatment monitoring.

Main Methods:

  • Analysis of maternal serum and cord blood M6P/IGFIIR levels.
  • Correlation studies between IGF-II:soluble M6P/IGFIIR ratio and anthropometric measurements (birth weight, placental weight).
  • Review of existing evidence linking soluble M6P/IGFIIR to various disease states.

Main Results:

  • Maternal serum M6P/IGFIIR levels increase in late pregnancy.
  • The IGF-II:soluble M6P/IGFIIR ratio in cord blood strongly correlates with birth weight and placental weight.
  • Elevated soluble M6P/IGFIIR levels are associated with liver cirrhosis and certain tumors.

Conclusions:

  • Soluble M6P/IGFIIR plays a significant role in fetal growth regulation.
  • It may serve as a useful biomarker for monitoring disease progression and treatment efficacy.
  • Further research is needed to fully understand the regulation and function of soluble M6P/IGFIIR in health and disease.
Keywords:
childhoodcirculating hormone binding proteininsulin-like growth factor IImannose-6-phosphate/IGF-II receptorobesityreceptor

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