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Animal models of pediatric chronic kidney disease. Is adenine intake an appropriate model?

Débora Claramunt1, Helena Gil-Peña2, Rocío Fuente1

  • 1University of Oviedo, Spain.

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|November 3, 2015
PubMed

Insights

Pediatric chronic kidney disease (CKD) causes growth impairment. This study evaluates rat models, including 5/6 nephrectomy and adenine diet, to understand CKD-related growth retardation in children.

Area of Science:

  • Pediatric Nephrology
  • Growth Biology
  • Animal Models in Research

Background:

  • Pediatric chronic kidney disease (CKD) is characterized by significant growth impairment.
  • Growth retardation impacts children's self-esteem and social integration.
  • CKD-related factors interfere with growth plate physiology, necessitating animal models for study.

Purpose of the Study:

  • To examine the characteristics of the 5/6 nephrectomy rat model for pediatric CKD growth retardation.
  • To analyze the high adenine diet-induced CKD model as an alternative research protocol.
  • To investigate mechanisms of growth plate dysfunction in pediatric CKD.

Main Methods:

  • Utilizing young rats as a model system.
  • Inducing chronic kidney disease via 5/6 nephrectomy.
  • Inducing chronic kidney disease via high adenine diet.

Main Results:

  • The 5/6 nephrectomy model is widely used to study CKD-induced growth retardation.
  • The high adenine diet offers an alternative protocol for inducing CKD in research settings.
  • Both models allow investigation into the interference with growth plate physiology.

Conclusions:

  • Animal models are crucial for studying growth plate dysfunction in pediatric CKD.
  • The 5/6 nephrectomy and adenine diet models provide valuable insights into growth impairment.
  • Further research using these models can elucidate therapeutic strategies for pediatric CKD growth issues.

Keywords:
5/6 nephrectomyAdeninaAdenineCKDCrecimientoERCExperimental modelsGrowthModelos experimentalesNefrectomía 5/6Uremia

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