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In Vitro Drug Dissolution: Alternative Methods

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...

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Related Experiment Video

Updated: Mar 30, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Double emulsion solvent evaporation techniques used for drug encapsulation.

Muhammad Iqbal¹, Nadiah Zafar¹, Hatem Fessi¹

¹University of Lyon, F-69622, Lyon, University Lyon-1, CNRS, UMR 5007, LAGEP-CPE, 43 bd 11 Novembre 1918, F-69622 Villeurbanne, France.

International Journal of Pharmaceutics

|November 3, 2015

Summary

Double emulsions offer advanced encapsulation for both hydrophobic and hydrophilic substances. Optimizing production parameters is key to achieving controlled droplet size and high encapsulation efficiency for diverse applications.

Keywords:

Control release Double emulsion Drug delivery Encapsulation Solvent evaporation Theranostics

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Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Published on: December 25, 2015

Area of Science:

Colloid and Surface Science
Materials Science
Pharmaceutical Sciences

Background:

Double emulsions, or "emulsions of emulsions," feature dispersed droplets containing smaller droplets.
They are crucial for encapsulating both hydrophobic and hydrophilic compounds, overcoming limitations of single emulsions for hydrophilic molecules.
Challenges include controlled production and achieving homogeneous droplet size.

Purpose of the Study:

To review the applications of double emulsion techniques for encapsulating various active substances.
To discuss the optimization of process variables and phase ratios for controlled double emulsion production.
To report on solvents, stabilizers, and polymers used in double emulsion encapsulation.

Main Methods:

Review of existing literature on double emulsion formation and application.
Analysis of process variables influencing droplet size and stability.
Compilation of data on encapsulation of drugs, proteins, and amino acids.

Main Results:

Double emulsions enhance encapsulation efficiency for hydrophilic molecules compared to single emulsions.
Successful encapsulation of anticancer, anti-inflammatory, and antibiotic drugs, as well as proteins and amino acids, is demonstrated.
Various solvents, stabilizers, and polymers have been investigated for optimizing encapsulation.

Conclusions:

Double emulsion technology provides a versatile platform for encapsulating a wide range of active substances.
Controlled production and optimization of process parameters are critical for successful application.
Double emulsions show significant potential in theranostics and drug delivery systems.