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Psoriatic Disease: Clinical Staging.

Raffaele Scarpa1, Francesco Caso2, Luisa Costa2

  • 1From the Rheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, and Academic Rheumatology Unit, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.R. Scarpa, MD, Rheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II; F. Caso, MD, PhD, Rheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, and Rheumatology Unit, Department of Medicine DIMED, University of Padua; L. Costa, MD; R. Peluso, MD, PhD; A. Spanò, MD, Department of Clinical Medicine and Surgery, University Federico II; E. Lubrano, MD, PhD, Academic Rheumatology Unit, Department of Medicine and Health Sciences, University of Molise; A. Del Puente, MD, PhD, Department of Clinical Medicine and Surgery, University Federico II; J.M. Moll, DM, PhD, FRCP, Emeritus Consultant Rheumatologist. rscarpa@unina.it.

The Journal of Rheumatology. Supplement
|November 3, 2015
PubMed
Summary
This summary is machine-generated.

Psoriatic disease (PsD) is now understood as a systemic condition, not limited to skin and joints. Targeting tumor necrosis factor effectively manages PsD's diverse symptoms, improving patient outcomes.

Keywords:
DISEASE-MODIFYING ANTIRHEUMATIC DRUGSINFLAMMATORY BOWEL DISEASESMETABOLIC SYNDROMEPSORIATIC ARTHRITISPSORIATIC DISEASETUMOR NECROSIS FACTOR-A BLOCKERS

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Area of Science:

  • Immunology
  • Rheumatology
  • Dermatology

Background:

  • Psoriatic disease (PsD) was traditionally viewed as limited to skin and joint manifestations.
  • The concept evolved in 2006 to recognize PsD as a systemic condition.
  • Increased tumor necrosis factor (TNF) activity is a key driver of PsD's molecular interactions.

Purpose of the Study:

  • To highlight the systemic nature of psoriatic disease.
  • To emphasize the role of TNF in PsD pathogenesis.
  • To discuss the impact of targeted therapies on managing PsD comprehensively.

Main Methods:

  • Review of current understanding of psoriatic disease pathogenesis.
  • Analysis of the impact of biologic therapies targeting TNF.
  • Evaluation of clinical manifestations beyond skin and joints.

Main Results:

  • PsD involves systemic inflammation, including inflammatory bowel disease, eye involvement, and metabolic syndrome.
  • TNF blockade has revolutionized therapeutic strategies for PsD.
  • Targeted therapies allow for adequate control of all clinical aspects of PsD.

Conclusions:

  • PsD is a systemic inflammatory condition driven by TNF.
  • Targeting specific molecular pathways offers effective management for diverse PsD manifestations.
  • Expanded clinical staging is recommended for optimal patient management and prognosis.