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Updated: Mar 30, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Papillion-Lefèvre Syndrome: Periodontists' Perspective.

Sunil Kumar Biraggari¹, K Krishna Mohana Reddy¹, J Sudhakar¹

¹G Pulla Reddy Dental College & Hospital, India.

Case Reports in Dentistry

|November 3, 2015

Summary

This summary is machine-generated.

Papillion-Lefèvre Syndrome, a rare genetic disorder, causes severe periodontitis and palmoplantar hyperkeratosis due to a Cathepsin C gene mutation. This case report details a 13-year-old female patient

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Area of Science:

Genetics
Dermatology
Periodontology

Background:

Papillion-Lefèvre Syndrome is a rare autosomal recessive disorder.
Characterized by palmoplantar hyperkeratosis and severe early-onset periodontitis.
Caused by mutations in the Cathepsin C gene on chromosome 11q14.

Purpose of the Study:

To report a case of Papillion-Lefèvre Syndrome in a 13-year-old female.
To describe the clinical presentation and management of the syndrome.
To highlight the link between genetic defect and oral manifestations.

Main Methods:

Clinical examination of oral and extraoral tissues.
Intraoral radiography to assess bone loss.
Periodontal therapy and ongoing maintenance.

Main Results:

The patient presented with characteristic palmoplantar hyperkeratosis.
Severe periodontitis with gingival inflammation, abscesses, and bone loss was observed.
Premature shedding of deciduous teeth was noted.

Conclusions:

Papillion-Lefèvre Syndrome requires early diagnosis and comprehensive management.
Periodontal therapy is crucial for managing the oral manifestations.
Genetic counseling and long-term follow-up are recommended.