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Updated: Mar 30, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

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Opioid-Induced Hyperalgesia: A Diagnostic Dilemma

Veronica Carullo, Ingrid Fitz-James, Ellise Delphin

    Journal of Pain & Palliative Care Pharmacotherapy
    |November 3, 2015
    PubMed
    Summary

    Opioid therapy for chronic pain can lead to opioid-induced hyperalgesia (OIH), a state of increased pain sensitivity. Recognizing OIH is crucial for effective pain management and may necessitate opioid rotation, such as to methadone.

    Keywords:
    acute or chronic paincancer painhyperalgesiamultimodal pain managementopioidopioid-induced androgen deficiencyphysical dependencetolerance

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