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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
Published on: December 27, 2017
[Analysis of Megakaryocytes and Platelet Parameters of ITP Patients]
1Department of Laboratorial Examination, Kaifeng Municipal Hospital of Traditioncal Chinese Medicine, Kaifeng 475000, Henan Province, China.
Objective:
To investigate the value of bone marrow megakaryocyte (BMK) and peripheral platelet parameter changes in differential diagnosis of idiopathic thrombocytopenic purpura (ITP).
Methods:
The 91 patients were divided into 2 groups: ITP group (46 cases) and non-ITP group (45 cases), while 48 healthy volunteers were used as healthy controls. The parameters of BMK and peripheral platelets of ITP and non-ITP patients, and parameters of peripheral platelets of healthy controls were detected and compared.
Results:
As compared with non-ITP group, the BMK count in ITP group obviously increased, including the gramlar MK and proo-MK, while the MK producing platelets obviously dicreased with statistical difference (P < 0.01); the platelet parameters in 2 groups did not show significant difference (P > 0.05). As compared with healthy control group, the platelet level and PCT of peripheral blood in ITP group significantly decreased (P < 0.01).
Conclusion:
The BMK level and platelet parameters, especially the platelet count and PCT have clinical value for differential diagnosis of ITP to a certain degree.
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