Related Experiment Video

Updated: Mar 30, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.7K

Streptococcus pneumoniae proteomics: determinants of pathogenesis and vaccine development

Mustapha Bittaye1, Phil Cash1

  • 1a Division of Applied Medicine , University of Aberdeen , Aberdeen , Scotland.

Expert Review of Proteomics
|November 3, 2015
PubMed

Insights

Streptococcus pneumoniae causes invasive diseases. Proteomics advances understanding of its mechanisms and protein-based vaccine development, addressing limitations of current polysaccharide vaccines.

Area of Science:

  • Microbiology
  • Immunology
  • Vaccinology

Background:

  • Streptococcus pneumoniae is a significant pathogen causing invasive diseases globally.
  • Initial colonization occurs in the nasopharynx, preceding systemic spread.
  • Existing polysaccharide-based vaccines have limitations in immunogenicity and serotype coverage.

Purpose of the Study:

  • To review the application of proteomic technologies in understanding Streptococcus pneumoniae pathogenesis.
  • To identify critical areas for developing novel protein-based vaccines against pneumococcal infections.

Main Methods:

  • This review synthesizes current knowledge on proteomic approaches.
  • Analysis of pathogenic mechanisms involved in nasopharyngeal colonization and disease progression.

Main Results:

  • Proteomics has enhanced understanding of bacterial virulence factors and host-pathogen interactions.
  • Identified key targets for protein-based vaccine development.
  • Highlighted challenges posed by the diversity of pneumococcal serotypes and isolates.

Conclusions:

  • Proteomic technologies offer valuable insights into Streptococcus pneumoniae pathogenesis.
  • Protein-based vaccines represent a promising strategy to overcome limitations of current vaccines.
  • Further research is needed to develop broadly effective vaccines against diverse pneumococcal strains.
Keywords:
Cell wall proteinsStreptococcus pneumoniaepathogenesisproteomevaccines

More Related Videos

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP009208:53

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

31.9K
Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae09:12

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae

Published on: January 17, 2014

13.3K

Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
4.1K
Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
29.7K
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
38
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.2K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.5K
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
99