The effectiveness of misoprostol or dinoprostone in neonatal outcome after labour induction in post-term nulliparas

The object of this study was to investigate the efficacy of vaginal administration of misoprostol versus dinoprostone in neonatal outcome.

The first Group A included 77 pregnant women, who requested pregnancy termination one week after labour term and received vaginally misoprostol 50 µg, while the other 69 pregnant women in Group B were vaginally administrated three mg dinoprostone. According to the authors' protocol this procedure was repeated after six hours for a maximum of two times.

The labour duration was longer in Group B (p = 0.000), while the APGAR score was better in Group A (p = 0.015). In Group A the labour modus was as follows: 86.9% normal vaginal labour, 3.8% vacuum extraction, and 9.3% cesarean section, while in Group B it was 82.83% normal vaginal labour, 3.07% vacuum extraction, and 14.1% cesarean section.

Misoprostol has advantages according to neonatal outcome compared to administration of dinoprostone.