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Updated: Mar 30, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Current and Future Therapies for Advanced Gastric Cancer
Michael Davidson1, Alicia F C Okines1, Naureen Starling1
1The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.
Advanced gastric cancer treatment is challenging. Targeted therapies like trastuzumab and ramucirumab, plus immunotherapy with pembrolizumab, show promise for improving patient survival beyond traditional chemotherapy.
Area of Science:
- Oncology
- Gastroenterology
- Molecular Biology
Background:
- Advanced gastric cancer treatment lacks an international consensus on optimal chemotherapy.
- Chemotherapy alone offers poor overall survival for patients with advanced gastric cancer.
- Recent advances in understanding molecular drivers offer new therapeutic strategies.
Purpose of the Study:
- To review current chemotherapy regimens for advanced gastric cancer.
- To describe advances in molecularly targeted agents.
- To outline the development and use of immune-modulating agents in gastric cancer treatment.
Main Methods:
- Review of clinical trial evidence for chemotherapy regimens.
- Analysis of data on targeted therapies including anti-HER2 and anti-VEGFR2 antibodies.
- Examination of preliminary results and ongoing trials for immunotherapies like checkpoint inhibitors.
Main Results:
- Trastuzumab (anti-HER2) significantly prolonged survival in first-line treatment for a molecularly selected subgroup.
- Ramucirumab (anti-VEGFR2) showed a modest survival benefit in previously treated patients.
- Pembrolizumab (anti-PD-1) demonstrates promising preliminary results in immunotherapy.
Conclusions:
- Targeted therapies and immunotherapies represent promising new avenues for advanced gastric cancer treatment.
- Continued research into novel targets and therapies is crucial for incremental survival gains.
- Molecularly targeted and immune-modulating agents are advancing gastric cancer care.
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