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Diastolic dysfunction diagnosed by tissue Doppler imaging in cirrhotic patients: Prevalence and its possible

Calogero Falletta1, Daniela Filì2, Cinzia Nugara3

  • 1Cardiology Unit, Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy.

European Journal of Internal Medicine
|November 4, 2015
PubMed

Insights

Diastolic dysfunction (DDF) affects over a quarter of cirrhotic patients but does not appear to worsen outcomes. Liver disease severity, not DDF, primarily determines prognosis in these patients.

Area of Science:

  • Cardiology
  • Hepatology
  • Gastroenterology

Background:

  • Cirrhotic cardiomyopathy involves impaired heart function in patients with liver cirrhosis.
  • Diastolic dysfunction (DDF) is a potential component, but its clinical significance remains unclear.

Purpose of the Study:

  • To determine the prevalence of DDF in cirrhotic patients with normal systolic function.
  • To investigate the association between DDF and clinical outcomes, including hospitalization and mortality.

Main Methods:

  • Eighty-four cirrhotic patients with normal systolic function were assessed for DDF using tissue Doppler imaging.
  • Patient outcomes, including hospitalization and causes of death, were monitored over a mean follow-up of 10 months.

Main Results:

  • Diastolic dysfunction (DDF) was diagnosed in 26.2% of patients.
  • DDF was more common in patients with ascites and lower albumin levels.
  • Patients with DDF did not experience higher rates of hospitalization or death compared to those without DDF.

Conclusions:

  • Diastolic dysfunction (DDF) in cirrhotic patients was not clearly associated with adverse outcomes.
  • Prognosis in cirrhotic patients is primarily dictated by the underlying severity of liver disease.
Abstract

Keywords:
CirrhosisDiastolic dysfunctionTissue Doppler imaging

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