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Regulatory T cells in cardiovascular diseases
Xiao Meng1, Jianmin Yang1, Mei Dong1
1The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, 107 Wen Hua Xi Road, Jinan, Shandong 250012, China.
Nature Reviews. Cardiology
|November 4, 2015
Summary
Regulatory T (TREG) cells modulate immune responses and inflammation, crucial for cardiovascular health. Dysregulation of TREG cells contributes to cardiovascular diseases, but they show promise for future cardioprotective therapies.
Area of Science:
- Immunology
- Cardiovascular Medicine
Background:
- Inflammation plays a key role in cardiovascular disease (CVD) development.
- CD4(+)CD25(+)FOXP3(+) regulatory T (TREG) cells are critical for immune homeostasis and tolerance.
- TREG cell dysregulation can lead to pathological immune responses.
Purpose of the Study:
- To review the role of TREG cells in the pathogenesis of various cardiovascular diseases.
- To highlight the potential of TREG cells in protecting against CVD.
Main Methods:
- Review of experimental and clinical studies.
- Overview of TREG cell involvement in CVD pathogenesis.
Main Results:
- TREG cells are implicated in the protection against atherosclerosis and abdominal aortic aneurysm.
- TREG cells play a role in the pathogenesis of hypertension, ischaemic stroke, Kawasaki disease, pulmonary arterial hypertension, myocardial infarction, myocarditis, dilated cardiomyopathy, and heart failure.
Conclusions:
- TREG cells are important in modulating immune responses in cardiovascular diseases.
- Targeted TREG cell therapies offer a promising future approach for CVD prevention and treatment, despite unknown molecular mechanisms.
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