Related Experiment Video
Updated: Mar 30, 2026
Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
Published on: September 13, 2024
[Migraine and temporomandibular joint dysfunction: mechanisms of comorbidity]
A S Zenkevich1, E G Filatova1, N V Latysheva1
1GBOU VPO 'Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova', Moskva.
Objective:
to analyze the frequency of different forms of temporomandibular joint dysfunction (TMJD) in episodic and chronic migraine and to study mechanisms of their comorbidity.
Material And Methods:
Sixty-three patients with chronic migraine (CM) and 40 patients with episodic migraine (EM) were examined. Anxiety and depression were assessed with the HADS, quality-of-life related to headache was measured with the HIT-6. To evaluate the antinociceptive system function, we studied blink reflex (BR) and nociceptive flexion reflex (NFR).
Results:
The higher frequency of TMJD was identified in patients with CM compared to those with EM (47.5 and 28.5%, respectively), CM patients more frequently had disturbances related to the myofascial pain syndrome of masticatory muscles. R3 BR and NFR thresholds were significantly decreased in CM patients as well.
Conclusion:
TMJD is a component of the pathogenesis in many patients with CM. Masticatory muscles may generate nociceptive impulses in CNS, ie be a source of peripheral sensitization, that promote pain chronification, including migraine. Dysfunction of masticatory muscles may reflect the central sensitization and disturbance of efferent pain control.
