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Updated: Mar 30, 2026

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
Published on: July 5, 2024
Effect of colchicine on polycystic ovary syndrome: an experimental study
Ilay Ozturk Gozukara1, Neslihan Pınar2, Oğuzhan Ozcan3
1Department of Obstetric and Gynecology, School of Medicine, Mustafa Kemal University, Tayfur Sökmen Kampus, Serinyol, 31000, Hatay, Turkey. ilayozt@gmail.com.
Purpose:
To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS).
Methods:
Twenty-two Wistar-Albino rats were randomly assigned into four with 8 rats in each group: control group; PCOS only group; PCOS-metformin group and PCOS-colchicine group. PCOS was induced by gavage with letrozole once daily at the concentration of 1 mg/kg orally with 21 consecutive days. After PCOS model assessment, PCOS-metformin group was received metformin orally with 500 mg/kg and PCOS-colchicine group was received colchicine orally with 1 mg/kg for the 35 day. Histopathology of ovaries, circulating estrone (E1), estradiol (E2), total testosterone, androstenedione and c-reactive protein (CRP) levels were evaluated.
Results:
cystic and atretic follicle number was significantly decreased, but CRP and hormone parameters were not significantly changed with colchicine treatment.
Conclusion:
Colchicine has provided histopathological improvement compared with metformin in PCOS rat model.
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