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[Cerebrovascular diseases: perspectives of pathogenetic metabolic haemangiocorrective treatment]

M M Tanashyan1, O V Lagoda1, K V Antonova1

  • 1Research Centre of Neurology, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|November 4, 2015
PubMed

Insights

Metabolic syndrome significantly increases the risk of cerebrovascular disease by affecting blood flow and clotting. Effective prevention and treatment require addressing metabolic factors and protecting blood vessels.

Area of Science:

  • Neurology
  • Cardiology
  • Metabolic Disorders

Background:

  • Metabolic syndrome is a major risk factor for cerebrovascular diseases, including stroke.
  • Key components like hyperinsulinemia, hypertension, dyslipidemia, and obesity contribute to proatherogenic effects.
  • These effects lead to significant hemorrheal and hemostasis changes, impacting cerebrovascular pathology.

Purpose of the Study:

  • To highlight the role of metabolic syndrome in cerebrovascular disease.
  • To discuss the influence of metabolic syndrome on antithrombotic therapy efficacy.
  • To propose comprehensive prevention and treatment strategies.

Main Methods:

  • Review of existing literature on metabolic syndrome and cerebrovascular disease.
  • Analysis of the pathophysiological mechanisms linking metabolic syndrome components to cerebrovascular pathology.
  • Evaluation of therapeutic approaches for patients with metabolic syndrome and cerebrovascular disease.

Main Results:

  • Metabolic syndrome components promote atherosclerosis and alter hemorrheal and hemostasis parameters.
  • These alterations are critical in the development and progression of cerebrovascular diseases.
  • Metabolic syndrome can compromise the effectiveness of standard antithrombotic therapies.

Conclusions:

  • Integrated management of metabolic syndrome is crucial for preventing and treating cerebrovascular disease.
  • Therapeutic strategies should encompass hemorrheal correction, antithrombotic, antioxidant, and endothelium-protective measures.
  • Addressing the core components of metabolic syndrome is essential for improving patient outcomes.

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